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Studies alopecia and and indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. When B12 is delivered via injection or lozenge treatment and alopecia it passes and throughout the bloodstream treatment before arriving at the liver. It is during alopecia and and this treatment first pass in its native form that it is believed to exert its therapeutic effect. CLINICAL RESEARCH: "The World Health Organization (WHO) recognizes allergic rhinitis (hay alopecia fever), and sinusitis, asthma,...conjunctivitis, urticaria, treatment eczema, dermatitis alopecia (contact and and atopic)...allergic and migraine headache...as diseases in which IgE-mediated allergy may be involved."1 In 1988, asthma and allergic treatment rhinitis subjects were treated alopecia with B12. Total IgE, specific and and treatment and alopecia IgE and and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. Eight of the 9 subjects had reduced IgE. 2 In 1989 open label studies at two sites in Riverside County, CA in 1989. Sixteen of the treatment 17 subjects had lowered IgE levels from Day 0 to Day 30.3

In January 1997, 62 subjects who had been the placebos in the 1995 alopecia study were invited to receive the vitamin B12. In June 1997, the 62 placebo subjects were sent a questionnaire and asking: How would you compare your overall allergy (hay fever) symptoms this spring to the last two springs? 20 people responded, with 15 reporting having had the B12 treatment, and 5 not. 12 of treatment the 15 reported at least a slight improvement alopecia in overall allergy symptoms, and 1 of the 5. Improvement ratios - 12:3 having received treatment, 1:4 not having received treatment.8 A bioequivalence study showed that a 3000 mcg lozenge and delivered an equivalent amount of cyanocobalamin to the blood as a 15 mcg injection.9 From the spring to the summer patients treatment with demonstrated allergic alopecia rhinitis received with the cyanocobalamin (or placebo) containing lozenge twice daily for 21 consecutive days. All subjects also received C and B oral multivitamins for 21 days. Twice daily subjects maintained a nine-week diary on sneezing, runny nose, nasal congestion, and itchy eyes, itchy nose and antihistamine (chlorpheniramine) use. In the post-treatment period, the active group treatment (n=15) recorded on average a greater reduction in symptoms and in antihistamine use than the placebo group (n=9). The results yielded reductions (0.1>p>0.01) in total weekly symptom/rescue medication for the active group compared to the placebo for weeks 2, 6, 8 and 9. The results tend to replicate those of the studies on injectable cyanocobalamin.10

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